Modeling and Simulation of Fission Yeast Cell Cycle on Hybrid Functional Petri Net
نویسندگان
چکیده
Through many researches on modeling and analyzing biological pathways, Petri net has recognized as a promising method for representing biological pathways. Recently, Matsuno et. al. (2003) introduced hybrid functional Petri net (HFPN) for giving more intuitive and natural biological pathway modeling method than existing Petri nets. They also developed Genomic Object Net (GON) which employs the HFPN as a basic architecture. Many kinds of biological pathways have been modeled with the HFPN and simulated by the GON. This paper gives a new HFPN model of “cell cycle of fission yeast” with giving six basic HFPN components of typical biological reactions, and demonstrating the method how biological pathways can be modeled with these HFPN components. Simulation results by GON suggest a new hypothesis which will help biologist for performing further experiments. key words: hybrid functional Petri net, Genomic Object Net, biological pathways, cell cycle, simulation
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